Y Chromosome-Specific STRs
نویسندگان
چکیده
The Y chromosome is one of the smallest human chromosomes with an average size of 60 million base pairs (Mb). Between X and Y chromosomes, exchange is limited to small pseudoautosomal regions (PAR) of the X-Y pair (see Figure 1). During male meiosis, recombination only takes place at the most distal short arm (PAR 1) and at the tip of the Y chromosome long arm (PAR 2). For most of its length (the nonrecombining portion or NRY) the Y chromosome is male-specific and effectively haploid and is transmitted from father to son unchanged unless a mutational event takes place.
منابع مشابه
Structure and polymorphism of 16 novel Y-STRs in Chinese Han population.
Y-chromosome short tandem repeats (Y-STRs) are useful tools for identifying paternity origin and male-female mixed samples because of their male-specificity, haploid inheritance and relatively simplicity. We focused on novel Y-STRs deposited in the human Genome database from DYS708 to DYS726. We typed 16 male-specific Y-STRs from males of a Chinese Han population residing in Shanxi Province (no...
متن کاملForensic value of 14 novel STRs on the human Y chromosome.
We identified and characterized 14 novel short-tandem-repeats (STRs) on the Y chromosome and typed them in two samples, a globally diverse panel of 73 cell lines, and 148 individuals from a European-American population. These Y-STRs include eight tetranucleotide repeats (DYS449, DYS453, DYS454, DYS455, DYS456, DYS458, DYS459, and DYS464), five pentanucleotide repeats (DYS446, DYS447, DYS450, DY...
متن کاملPopulation-Scale Sequencing Data Enable Precise Estimates of Y-STR Mutation Rates.
Short tandem repeats (STRs) are mutation-prone loci that span nearly 1% of the human genome. Previous studies have estimated the mutation rates of highly polymorphic STRs by using capillary electrophoresis and pedigree-based designs. Although this work has provided insights into the mutational dynamics of highly mutable STRs, the mutation rates of most others remain unknown. Here, we harnessed ...
متن کاملDecreased Rate of Evolution in Y Chromosome STR Loci of Increased Size of the Repeat Unit
BACKGROUND Polymorphic Y chromosome short tandem repeats (STRs) have been widely used in population genetic and evolutionary studies. Compared to di-, tri-, and tetranucleotide repeats, STRs with longer repeat units occur more rarely and are far less commonly used. PRINCIPAL FINDINGS In order to study the evolutionary dynamics of STRs according to repeat unit size, we analysed variation at 24...
متن کاملRecent Developments in Y-Short Tandem Repeat and Y-Single Nucleotide Polymorphism Analysis.
This article reviews new genetic markers on the Y-chromosome and methods for analyzing these short tandem repeat (STR) and single nucleotide polymorphism (SNP) loci. Relative chromosomal locations for over 50 Y-chromosome STRs (Y-STRs) are described along with their repeat motif and allele range characteristics based on published population studies. Multiplex assays for typing many of these mar...
متن کامل